LIPA 抗体-抗体-抗体-生物在线
上海信裕生物科技有限公司
LIPA 抗体

LIPA 抗体

商家询价

产品名称： LIPA 抗体

英文名称： LIPA Antibody

产品编号： XY12956-1

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

上海信裕生物科技有限公司
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  • 邮编 : 200612
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 LIPA 抗体

Applications
In-house applications ELISA, WB, IHC     Application not tested? Please see our Guarantee.
Species specificity Human,Mouse,Rat; other species not tested.
Images
Prev1NextView more validation data
  • 12956-1-AP;Y79 cellsY79 cells were subjected to SDS PAGE followed by western blot with 12956-1-AP(LIPA antibody) at dilution of 1:400
  • 12956-1-AP;human colon cancerImmunohistochemical of paraffin-embedded human colon cancer using 12956-1-AP(LIPA antibody) at dilution of 1:100 (under 10x lens)
Positive WB detected in Y79 cells, HEK-293 cells, HeLa cells, HepG2 cells, HT-1080 cells
Positive IHC detected in Human colon cancer tissue
Recommended dilution WB : 1:200-1:2000
IHC : 1:20-1:200
 LIPA 抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information
Immunogen LIPA fusion protein ag3627 Full name Lipase A, lysosomal acid, cholesterol esterase
Calculated molecular
weight		 399aa,45 kDa Observed molecular 
weight		 45kd
GenBank accession 
number		 BC012287 Gene ID (NCBI) 3988
Gene symbol LIPA Synonyms CESD, Cholesteryl esterase, LAL, LIPA, Lipase A, Sterol esterase
Background LIPA 抗体

Human acid lipase/cholesteryl esterase (LIPA) is a 46-kDa glycoprotein required for the lysosomal hydrolysis of cholesteryl esters and triglycerides that cells acquire through the receptor-mediated endocytosis of low-density lipoproteins(PMID:8432549). Defects in LIPA are the cause of Wolman disease (WOD)(PMID:8146180) and cholesteryl ester storage disease (CESD)(PMID:9633819). It has 2 isoforms produced by alternative splicing with the molecular weight of 45 kDa and 39 kDa. The full length protein has a signal peptide and several glycosylation sites. LIPA 抗体

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