NR1I3 (Human) Recombinant Protein (Q01)
产品名称： NR1I3 (Human) Recombinant Protein (Q01)
英文名称： NR1I3 (Human) Recombinant Protein (Q01)
产品编号： H00009970-Q01
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Human NR1I3 partial ORF ( NP_005113.1, 2 a.a. - 59 a.a.) recombinant protein with GST-tag at N-terminal.
- Sequence:
- ASREDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQ
- Theoretical MW (kDa):
- 32.12
- Preparation Method:
- in vitro wheat germ expression system
- Purification:
- Glutathione Sepharose 4 Fast Flow
- Storage Buffer:
- 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
- Storage Instruction:
- Store at -80°C. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- 12.5% SDS-PAGE Stained with Coomassie Blue.
- Note:
- Best use within three months from the date of receipt of this protein.
- MSDS:
Download
- Application Image
- Enzyme-linked Immunoabsorbent Assay
- Western Blot (Recombinant protein)
- Antibody Production
- Protein Array
- Entrez GeneID:
- 9970
- GeneBank Accession#:
- NM_005122
- Protein Accession#:
- NP_005113.1
- Gene Name:
- NR1I3
- Gene Alias:
- CAR,CAR1,MB67,MGC150433,MGC97144,MGC97209
- Gene Description:
- nuclear receptor subfamily 1, group I, member 3
- Omim ID:
- 603881
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- OTTHUMP00000032245,OTTHUMP00000032246,constitutive activator of retinoid response,constitutive active receptor,constitutive androstane receptor,orphan nuclear hormone receptor
- Related Disease