UPF2 polyclonal antibody
产品名称： UPF2 polyclonal antibody
英文名称： UPF2 polyclonal antibody
产品编号： PAB6940
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Goat polyclonal antibody raised against synthetic peptide of UPF2.
- Immunogen:
- A synthetic peptide corresponding to human UPF2.
- Sequence:
- C-PRYQHPKGAPNAD
- Host:
- Goat
- Theoretical MW (kDa):
- 148
- Specificity:
- This antibody is expected to recognize both reported isoforms (NP_542166.1; NP_056357.1).
- Form:
- Liquid
- Purification:
- Antigen affinity purification
- Concentration:
- 0.5 mg/mL
- Storage Buffer:
- In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- ELISA (1:4000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- CBP80 promotes interaction of Upf1 with Upf2 during nonsense-mediated mRNA decay in mammalian cells.
Hosoda N, Kim YK, Lejeune F, Maquat LE.Nat Struct Mol Biol. 2005 Oct;12(10):893-901. Epub 2005 Sep 25.
- Application Image
- ELISA
- Entrez GeneID:
- 26019
- Protein Accession#:
- NP_542166.1;NP_056357.1
- Gene Name:
- UPF2
- Gene Alias:
- DKFZp434D222,HUPF2,KIAA1408,MGC138834,MGC138835,RENT2,smg-3
- Gene Description:
- UPF2 regulator of nonsense transcripts homolog (yeast)
- Omim ID:
- 605529
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein. [provided by RefSeq
- Other Designations:
- OTTHUMP00000019091,OTTHUMP00000019092,OTTHUMP00000045025,UPF2 regulator of nonsense transcripts homolog,regulator of nonsense transcripts 2,yeast Upf2p homolog