MAP4K2 polyclonal antibody
产品名称： MAP4K2 polyclonal antibody
英文名称： MAP4K2 polyclonal antibody
产品编号： PAB4603
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of MAP4K2.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to internal region of human MAP4K2.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2.
Chadee DN, Yuasa T, Kyriakis JM.Mol Cell Biol. 2002 Feb;22(3):737-49.
- 2.
- Differential expression of a novel protein kinase in human B lymphocytes. Preferential localization in the germinal center.
Katz P, Whalen G, Kehrl JH.J Biol Chem. 1994 Jun 17;269(24):16802-9.
- Applications
- Western Blot (Tissue lysate)
- The MAP4K2 polyclonal antibody (Cat # PAB4603) is used in Western blot to detect MAP4K2 in mouse skeletal muscle tissue lysate .
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with MAP4K2 polyclonal antibody (Cat # PAB4603) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining . This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated . HC = hepatocarcinoma .
- Entrez GeneID:
- 5871
- Protein Accession#:
- M4K2_HUMAN
- Gene Name:
- MAP4K2
- Gene Alias:
- BL44,GCK,RAB8IP
- Gene Description:
- mitogen-activated protein kinase kinase kinase kinase 2
- Omim ID:
- 603166
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. [provided by RefSeq
- Other Designations:
- B lymphocyte serine/threonine protein kinase,Rab8 interacting protein,germinal centre kinase (GC kinase)
- Gene Pathway
- Related Disease