KLRD1 monoclonal antibody, clone HP-3D9
产品名称： KLRD1 monoclonal antibody, clone HP-3D9
英文名称： KLRD1 monoclonal antibody, clone HP-3D9
产品编号： MAB6947
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against native KLRD1.
- Immunogen:
- Native purified KLRD1 from cultured human NK cells .
- Host:
- Mouse
- Reactivity:
- Human
- Form:
- Liquid
- Isotype:
- IgG1
- Storage Buffer:
- In 50 mM sodium phosphate buffer, 100 mM potassium Chloride, 150 mM NaCl, pH 7.5 (0.5 mg/mL gentamicin sulfate)
- Storage Instruction:
- Store at 4°C.
- Recommend Usage:
- The optimal working dilution should be determined by the end user.
- Publication Reference
- 1.
- Molecular characterization of human CD94: a type II membrane glycoprotein related to the C-type lectin superfamily.
Chang C, Rodriguez A, Carretero M, Lopez-Botet M, Phillips JH, Lanier LL.Eur J Immunol. 1995 Sep;25(9):2433-7.
- 2.
- Human natural killer cell receptors for HLA-class I molecules. Evidence that the Kp43 (CD94) molecule functions as receptor for HLA-B alleles.
Moretta A, Vitale M, Sivori S, Bottino C, Morelli L, Augugliaro R, Barbaresi M, Pende D, Ciccone E, Lopez-Botet M, Moretta L.J Exp Med. 1994 Aug 1;180(2):545-55.
- 3.
- A novel functional cell surface dimer (Kp43) expressed by natural killer cells and T cell receptor-gamma/delta+ T lymphocytes. I. Inhibition of the IL-2-dependent proliferation by anti-Kp43 monoclonal antibody.
Aramburu J, Balboa MA, Ramirez A, Silva A, Acevedo A, Sanchez-Madrid F, De Landazuri MO, Lopez-Botet M.J Immunol. 1990 Apr 15;144(8):3238-47.
- Applications
- Flow Cytometry
- Ficoll prepared human peripheral white blood cells were stimulated by incubating 1 day at 5 x 106 cells/mL in RPMI 10% FBS media including 5 ug/mL Phytohemagglutinin-P. 5 X 105 cells per tube were then washed and incubated 45 minutes on ice with 80 uL of KLRD1 monoclonal antibody, clone HP-3D9 (Cat # MAB6947) at a concentration of 20 ug/mL. Cells were washed twice and incubated with 2oreagent Goat anti-Mouse IgG/FITC, after which they were washed three times, fixed and analyzed by FACS. A net 40% population of the cells stained positive with a mean shift of 1.10 log10 fluorescent units when compared to a Mouse IgG1 negative control at a similar concentration.
- Entrez GeneID:
- 3824
- Gene Name:
- KLRD1
- Gene Alias:
- CD94
- Gene Description:
- killer cell lectin-like receptor subfamily D, member 1
- Omim ID:
- 602894
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- CD94 antigen