KIR2DL2 monoclonal antibody, clone GL183-抗体-抗体-生物在线

产品名称： KIR2DL2 monoclonal antibody, clone GL183

英文名称： KIR2DL2 monoclonal antibody, clone GL183

产品编号： MAB4187

产品价格： null

产品产地：台湾

品牌商标： Abnova

更新时间： null

使用范围：

亚诺法生技股份有限公司（Abnova)

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Specificity:
GL183 monoclonal antibody immunoprecipitates the p58.2 molecule, a 58KDa type I transmembrane protein. It can also react with a lighter (p50.2, 50KDa) molecule, highly homologous to p58.2 in the extracellular area, but exhibiting a shorter cytoplasmic tail. These p58.2 and 50.2 molecules are characterized by two immunoglobulin-like extracellular domains. They are expressed by human NK cell subsets and by human T lymphocytes subsets, the latest being, in most instances, CD8+CD4-TCR alpha beta+. p58.2 and p50.2 are members of the newly described natural killer cell receptor (NK-R) family. Clone GL183 can restore in vitro the lysis by human NK clones of otherwise lysis-protected targets carrying the Cw3 or related alleles. Clone GL183 has been assigned to the CD158b cluster of differentiation of the VIth International Workshop on human Leucocyte Differentiation Antigens (HLDA) in Kobe, 1996.

Storage Instruction:
Store at 4°C on dry atmosphere.
After reconstitution with distilled water, store at -20°C.
Aliquot to avoid repeated freezing and thawing.

Recommend Usage:
Flow Cytometry (2ug/5x10⁵ cells or 100ul whole blood per test)
The optimal working dilution should be determined by the end user.

2.
NK-cell receptors and recognition of MHC class I molecules.
Lopez-Botet M, Moretta L, Strominger J.Immunol Today. 1996 May;17(5):212-4.

3.
Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains.
Wagtmann N, Biassoni R, Cantoni C, Verdiani S, Malnati MS, Vitale M, Bottino C, Moretta L, Moretta A, Long EO.Immunity. 1995 May;2(5):439-49.

Gene Summary:
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq