Uniprot ID:O89106
Species Reactivity:Mouse
Antibody type:Polyclonal Antibody
Aliases:AP3A hydrolase,Diadenosine 5,5-P1,P3-triphosphate hydrolase,Dinucleosidetriphosphatase,Fragile histidine triad protein,FhitRaised in:Rabbit
Background\Function :Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity (By similarity). Functions as tumor suppressor.
Stroage Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purity:Caprylic Acid Ammonium Sulfate Precipitation purified
武汉华美生物工程有限公司专营基因、蛋白、抗体、ELISA试剂盒、诊断试剂原料、药物残留、食品安全小分子及其他小分子等高质量生物产品，我们的产品涉及血管生成、细胞凋亡/自噬、合成/代谢、血液凝固、细胞粘附、细胞周期、补体、发育蛋白、DNA损伤/DNA修复、细胞因子、药物残留与食品安全、受精作用、生长因子、神经生物学、氧化应激、信息受体、转录/转录调控、运输、泛素、信号传导通路、自身免疫等多个研究领域，包括涵盖37个种属的多达万种的ELISA试剂盒。详细信息请登录：www.cusabio.cn/