MMP7 (Center) Peptide
产品名称： MMP7 (Center) Peptide
英文名称： MMP7 (Center) Peptide
产品编号： P1820
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of MMP7.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to internal region of human MMP7.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Matrilysin-dependent elastolysis by human macrophages.
Filippov S, Caras I, Murray R, Matrisian LM, Chapman HA Jr, Shapiro S, Weiss SJ.J Exp Med. 2003 Sep 15;198(6):925-35. Epub 2003 Sep 8.
- 2.
- Synergistic cooperation between the AP-1 and LEF-1 transcription factors in activation of the matrilysin promoter by the src oncogene: implications in cellular invasion.
Rivat C, Le Floch N, Sabbah M, Teyrol I, Redeuilh G, Bruyneel E, Mareel M, Matrisian LM, Crawford HC, Gespach C, Attoub S.FASEB J. 2003 Sep;17(12):1721-3. Epub 2003 Jul 18.
- 3.
- Hypochlorous acid generated by myeloperoxidase modifies adjacent tryptophan and glycine residues in the catalytic domain of matrix metalloproteinase-7 (matrilysin): an oxidative mechanism for restraining proteolytic activity during inflammation.
Fu X, Kassim SY, Parks WC, Heinecke JW.J Biol Chem. 2003 Aug 1;278(31):28403-9. Epub 2003 May 20.
- Applications
- Western Blot (Cell lysate)
- The MMP7 polyclonal antibody (Cat # PAB4796) is used in Western blot to detect MMP7 in 293 cell lysate.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human cancer tissue reacted with MMP7 polyclonal antibody (Cat # PAB4796) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.
- Entrez GeneID:
- 4316
- Protein Accession#:
- MM7_HUMAN
- Gene Name:
- MMP7
- Gene Alias:
- MMP-7,MPSL1,PUMP-1
- Gene Description:
- matrix metallopeptidase 7 (matrilysin, uterine)
- Omim ID:
- 178990
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq
- Other Designations:
- matrin,matrix metalloproteinase 7,matrix metalloproteinase 7 (matrilysin, uterine),uterine matrilysin
- Interactome
- Gene Pathway
- Related Disease
- Adenocarcinoma
- Adenomatous Polyps
- Arthritis, Rheumatoid
- Astrocytoma
- Atherosclerosis
- Atrophy
- Brain Neoplasms
- Breast cancer
- Breast Neoplasms
- Bronchiolitis Obliterans
- Carcinoma
- Carcinoma, Hepatocellular
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Squamous Cell
- Chorioamnionitis
- Colorectal Neoplasms
- Coronary Artery Disease
- Disease Progression
- Duodenal Ulcer